Enhanced-Delivery Antioxidant Support for Cellular Health, Liver Function and Healthy Aging

Strengthen your body’s natural antioxidant defenses with Pure Encapsulations Liposomal Glutathione, an advanced glutathione softgel formulated with protective phospholipids for improved stability during digestion.

Each softgel provides 250 mg of Setria® reduced glutathione and 125 mg of essential phospholipids in a 375 mg BioGlute™ liposomal complex.

Glutathione is an antioxidant produced naturally throughout the body and found in virtually every cell. It helps protect cells from free radicals, supports normal enzyme activity and participates in the liver’s natural detoxification processes.

The liposomal delivery system surrounds glutathione with phospholipids that help protect its peptide bonds from digestive degradation and support movement across intestinal membranes. This makes Liposomal Glutathione a convenient option for adults seeking direct glutathione supplementation for antioxidant protection, cellular resilience, liver wellness and healthy aging.

Benefits of Liposomal Glutathione

Liposomal Glutathione supports:

• Cellular antioxidant defenses

• Protection from oxidative stress

• Healthy cellular function

• Liver health

• Natural detoxification pathways

• Phase II conjugation processes

• Healthy oxidative status

• Normal lipid metabolism

• Mitochondrial protection

• Cellular repair and maintenance

• Long-term resilience and healthy aging

What Is Glutathione?

Glutathione is a small peptide made from three amino acids:

• Cysteine

• Glycine

• Glutamate

The body produces glutathione internally, but levels and requirements can be influenced by age, diet, physical stress, environmental exposure, alcohol intake, health status and the availability of its amino-acid building blocks.

Glutathione is concentrated in tissues with substantial metabolic or detoxification demands, including the liver. It also plays important roles in cellular defense systems throughout the body.

Glutathione contributes to:

• Neutralization of free radicals

• Recycling of other antioxidants

• Normal enzyme function

• Cellular protein synthesis

• Cell maturation and transport

• Detoxification reactions

• Protection of cellular structures

• Maintenance of normal redox balance

250 mg of Setria® Glutathione per Softgel

Each softgel provides:

BioGlute™ proprietary blend — 375 mg

Providing:

• Setria® reduced glutathione — 250 mg

• Essential phospholipid complex — 125 mg

Setria® is a high-quality reduced glutathione produced through corn-glucose fermentation.

Reduced glutathione is the active antioxidant form capable of donating electrons to help neutralize reactive compounds.

Why Use Liposomal Glutathione?

Glutathione is a peptide, which means its amino acids are connected by peptide bonds. These bonds can be affected by enzymes within the digestive tract.

Glutathione also does not move easily across cell membranes on its own.

Liposomal delivery addresses these limitations by surrounding glutathione with a phospholipid structure. Phospholipids contain both water-compatible and fat-compatible regions, allowing them to form small spherical particles known as liposomes.

The liposomal system helps:

• Protect glutathione during digestion

• Improve its dispersion within the digestive tract

• Support passage across intestinal cell membranes

• Preserve the integrity of glutathione’s peptide bonds

• Deliver glutathione in a convenient softgel format

Laboratory testing has shown greater movement across an intestinal-cell model with this liposomal formula than with a matching non-liposomal glutathione powder. Human responses may still vary.

Powerful Cellular Antioxidant Support

Normal metabolism continuously produces reactive compounds known as free radicals.

Exercise, environmental pollutants, inadequate sleep, alcohol, tobacco exposure and other physical demands can also increase oxidative stress.

Antioxidant systems help keep these reactive compounds in balance. Glutathione is especially important because it can work both directly and through glutathione-dependent enzymes.

Glutathione supports cellular protection by:

• Donating electrons to reactive compounds

• Supporting glutathione peroxidase activity

• Helping neutralize hydrogen peroxide

• Protecting cellular membranes and proteins

• Supporting normal redox balance

• Participating in the recycling of other antioxidants

Oxidative stress is a normal biological process, and antioxidants should not be viewed as eliminating every free radical. The goal is to support a healthy balance between reactive compounds and the body’s protective systems.

Glutathione Peroxidase and Hydrogen Peroxide

Hydrogen peroxide is produced during normal cellular and mitochondrial energy metabolism.

Although it also functions as a signaling molecule, excessive hydrogen peroxide can affect cellular membranes, proteins and other structures.

Glutathione serves as a co-substrate for glutathione peroxidase enzymes. These enzymes help convert hydrogen peroxide and certain lipid peroxides into less reactive compounds.

This makes glutathione an important part of the body’s internal antioxidant network.

Liver and Detoxification Support

The liver is a primary site for the processing of hormones, metabolic byproducts, medications and environmental compounds.

Glutathione is found in particularly high concentrations in liver tissue, where it contributes to antioxidant protection and Phase II detoxification.

During Phase II conjugation, glutathione can be attached to certain compounds. This process may make those compounds less reactive and easier for the body to process and eliminate.

Liposomal Glutathione supports:

• Normal liver antioxidant defenses

• Healthy Phase II conjugation

• Cellular protection within liver tissue

• Processing of normal metabolic byproducts

• Healthy detoxification pathways

• Normal hepatic lipid metabolism

This product is not a “detox cleanse” and does not remove every toxin from the body. It supports the liver’s existing biological processes.

What Does Detoxification Support Mean?

Detoxification is an ongoing physiological process carried out primarily by the liver, kidneys, digestive tract, lungs and other tissues.

Effective detoxification depends on more than one supplement. It also requires:

• Adequate protein and amino acids

• Sufficient dietary fiber

• Regular bowel movements

• Hydration

• Healthy kidney and liver function

• Appropriate intake of vitamins and minerals

• Limited tobacco and excessive alcohol exposure

• Reduced unnecessary environmental exposure

• Adequate sleep

Liposomal Glutathione provides targeted antioxidant and conjugation support within this broader system.

It is not intended to treat poisoning, chemical exposure, liver failure or another medical emergency.

Healthy Lipid Metabolism and Oxidative Status

Lipids are essential components of cellular membranes and energy metabolism. However, lipids may be vulnerable to oxidative damage.

Glutathione-dependent antioxidant activity helps protect cellular lipids and contributes to a healthy oxidative environment.

Liposomal Glutathione supports normal lipid metabolism as part of a complete routine that includes:

• Balanced nutrition

• Healthy body composition

• Regular exercise

• Adequate omega-3 intake

• Normal glucose metabolism

• Appropriate cholesterol and triglyceride monitoring

It should not replace cholesterol medication or professional treatment for abnormal lipid levels.

Mitochondrial and Cellular-Energy Support

Mitochondria convert nutrients into usable cellular energy. This process naturally generates reactive compounds, including hydrogen peroxide.

Glutathione helps protect mitochondrial and cellular structures from excessive oxidative stress generated during energy production.

Liposomal Glutathione can complement a mitochondrial-support routine that includes:

• Ubiquinol-QH

• Magnesium Glycinate

• Creatine

• O.N.E. Multivitamin

• O.N.E. Omega

• Regular physical activity

• Quality sleep

Glutathione does not act as a stimulant and will not create the immediate energy surge associated with caffeine.

Glutathione and Healthy Aging

The ability to maintain antioxidant balance and cellular resilience is an important component of healthy aging.

Glutathione production and status can be affected by age, nutritional intake, oxidative demand and health conditions. Supporting glutathione availability may help maintain the cellular systems involved in long-term physical function.

Liposomal Glutathione supports a healthy-aging routine by promoting:

• Cellular antioxidant protection

• Liver function

• Mitochondrial resilience

• Normal enzyme activity

• Healthy oxidative balance

• Cellular repair and maintenance

• Long-term metabolic wellness

Glutathione does not stop aging or prevent age-related disease. It provides nutritional support for biological systems involved in cellular protection and resilience.

Liposomal Glutathione vs. NAC + Glycine

Both products support glutathione status, but they do so differently.

Liposomal Glutathione

Liposomal Glutathione provides preformed reduced glutathione directly within a phospholipid delivery system.

It may be preferred by adults who want:

• Direct glutathione supplementation

• A convenient softgel

• Liposomal delivery

• No flavored powder

• A shelf-stable formula

NAC + Glycine

NAC + Glycine provides cysteine and glycine, two amino-acid building blocks the body uses to produce its own glutathione.

It may be preferred by adults who want:

• Glutathione-precursor support

• Larger amounts of NAC and glycine

• Additional respiratory support from NAC

• A vegan powder

• A flavored drink format

One option is not automatically superior for every person. The most appropriate choice depends on dietary preferences, digestive tolerance, supplement format and health goals.

Can Liposomal Glutathione and NAC + Glycine Be Combined?

They support glutathione through complementary approaches: one provides preformed glutathione, while the other provides two of its primary precursors.

However, combining both may be unnecessary for many customers. A healthcare professional can help determine whether using both products provides a meaningful benefit based on health history, oxidative demands and current supplementation.

Liposomal Glutathione Capsules vs. Liquid

Pure Encapsulations offers both capsule and liquid liposomal glutathione formulas, but they are separate products with different ingredients and directions.

This capsule formula provides:

• 250 mg of glutathione per softgel

• 125 mg of essential phospholipids

• One softgel one to two times daily

• Convenient use with meals

• Shelf-stable storage

• No measuring or pumping

The capsule format may be preferable for customers who value convenience, portability and precise serving amounts.

Shelf-Stable Softgel Formula

Unlike some probiotic and liquid products, Liposomal Glutathione softgels do not require refrigeration.

Store the bottle in a cool, dry place and protect it from excessive heat, moisture and direct sunlight.

The softgel format contains gelatin, glycerin, water, calcium carbonate, extra-virgin olive oil and beeswax.

Because it contains gelatin and beeswax, this product is not suitable for vegan or vegetarian diets.

Product Highlights

• 250 mg of Setria® reduced glutathione per softgel

• 125 mg of essential phospholipids per softgel

• 375 mg BioGlute™ liposomal complex

• Supports cellular antioxidant defenses

• Supports liver health

• Supports natural detoxification pathways

• Supports healthy oxidative status

• Supports normal lipid metabolism

• Helps protect cellular structures from free radicals

• Liposomal delivery protects glutathione during digestion

• Shelf-stable

• Convenient once- or twice-daily softgel

• Available in 30- and 60-softgel bottles

• Glutathione produced through corn-glucose fermentation

• Non-GMO

• Free from artificial colors and sweeteners

• Free from unnecessary fillers and preservatives

• Contains soy

• Contains gelatin and beeswax

• Not vegan or vegetarian

Supplement Facts

Each softgel provides:

BioGlute™ proprietary blend of glutathione and essential phospholipids — 375 mg

Providing:

• Setria® reduced glutathione — 250 mg

• Phospholipid complex — 125 mg

Other ingredients include gelatin capsule, glycerin, water, calcium carbonate, extra-virgin olive oil and beeswax.

Contains soy.

Suggested Use

Take one softgel one to two times daily with meals, or as directed by a qualified healthcare professional.

When using two softgels daily, the servings may be divided between two meals.

Do not exceed the suggested use unless professionally directed.

Frequently Asked Questions

What is Pure Encapsulations Liposomal Glutathione?

Pure Encapsulations Liposomal Glutathione is an antioxidant and liver-support supplement that provides reduced glutathione within a protective phospholipid complex.

Each softgel supplies 250 mg of Setria® glutathione and 125 mg of essential phospholipids.

How much glutathione is in each softgel?

Each softgel provides 250 mg of Setria® reduced glutathione.

It also contains 125 mg of essential phospholipids, for a total BioGlute™ liposomal complex of 375 mg.

What is Setria® glutathione?

Setria® is a branded form of reduced glutathione produced through fermentation.

Reduced glutathione is the antioxidant form used by the body to support cellular protection and glutathione-dependent enzyme activity.

What is BioGlute™?

BioGlute™ is the proprietary liposomal complex used in this formula.

It combines Setria® glutathione with essential phospholipids to protect glutathione during digestion and support absorption across intestinal membranes.

What does “liposomal” mean?

A liposome is a small spherical structure formed from phospholipids.

The phospholipids surround the active ingredient and help protect it from digestive degradation while supporting movement across biological membranes.

Is liposomal glutathione better absorbed than regular glutathione?

The liposomal system is designed to improve stability and absorption.

Laboratory testing using an intestinal-cell model showed greater permeability for this formula than for a matching non-liposomal glutathione powder. This does not guarantee the same response in every person.

What does glutathione do?

Glutathione supports:

• Antioxidant defenses

• Neutralization of free radicals

• Normal enzyme activity

• Cellular protection

• Liver function

• Detoxification pathways

• Mitochondrial resilience

• Healthy oxidative balance

Is glutathione the body’s “master antioxidant”?

Glutathione is sometimes described this way because it is widely distributed and participates in numerous antioxidant and detoxification processes.

However, the body uses an interconnected network of antioxidants rather than relying on one compound alone.

Does Liposomal Glutathione support liver health?

Yes. Glutathione is found in high concentrations in liver tissue and supports antioxidant protection and normal Phase II conjugation.

It is not a treatment for fatty liver disease, hepatitis, cirrhosis or another liver condition.

Does glutathione detox the body?

Glutathione supports the body’s normal detoxification pathways, particularly certain Phase II conjugation reactions in the liver.

It does not act as a cleanse or instantly remove accumulated toxins.

What is Phase II detoxification?

Phase II detoxification includes enzymatic reactions that attach molecules such as glutathione to certain compounds.

This process can make the compounds less reactive and support their normal processing and elimination.

Does Liposomal Glutathione support antioxidant defenses?

Yes. Reduced glutathione can donate electrons to reactive compounds and supports glutathione-dependent antioxidant enzymes.

Does glutathione support mitochondrial health?

Yes. Glutathione helps protect mitochondria and other cellular structures from excessive oxidative stress generated during normal energy production.

Does Liposomal Glutathione support healthy aging?

It supports antioxidant defenses, liver function, mitochondrial protection and cellular resilience, all of which are relevant to healthy aging.

It should not be represented as preventing aging or extending lifespan.

Does glutathione support immunity?

Glutathione is involved in normal cellular and immune function, but this specific formula is primarily positioned for antioxidant, cellular and liver support.

It is not intended to prevent or treat infections.

Can glutathione improve skin tone or lighten skin?

Glutathione is sometimes promoted online for skin-lightening purposes, but results are inconsistent and this product is not formulated or marketed as a skin-bleaching treatment.

Changes in pigmentation should be discussed with a qualified dermatologist.

Is Liposomal Glutathione good for gut health?

Its primary benefits relate to antioxidant protection, cellular health and liver detoxification.

It may complement a broader gut and digestive-health routine because liver, bile and intestinal function are interconnected, but it is not a probiotic, digestive enzyme or fiber supplement.

How many softgels should I take?

Take one softgel one to two times daily with meals.

Should Liposomal Glutathione be taken with food?

Yes. The suggested use is with meals.

The phospholipid and oil-based softgel is designed to be taken alongside food.

What is the best time to take Liposomal Glutathione?

Take it with breakfast, lunch or another meal.

When using two softgels daily, divide them between two meals unless a healthcare professional recommends another schedule.

Can I take both softgels together?

The label allows one softgel one to two times daily.

Dividing the servings across two meals may provide a more consistent routine, although individualized professional guidance may differ.

Can I take Liposomal Glutathione every day?

Yes. It is formulated for daily use by adults when appropriate for their health status.

Long-term supplementation should be reviewed with a healthcare professional when medications or medical conditions are involved.

How long does Liposomal Glutathione take to work?

Glutathione is nutritional support rather than a stimulant or fast-acting medication.

The response depends on baseline glutathione status, oxidative demands, diet, consistency and the outcome being evaluated.

Will I feel an immediate effect?

Many people do not feel an immediate sensation from antioxidant supplementation.

Lack of an immediate feeling does not necessarily indicate that the product is not being absorbed or used.

Does Liposomal Glutathione provide energy?

It supports cellular and mitochondrial protection but does not contain caffeine or stimulants.

It should not be expected to produce an immediate energy boost.

Does Liposomal Glutathione contain caffeine?

No caffeine is listed in the formula.

Is Liposomal Glutathione the same as NAC?

No.

Liposomal Glutathione provides preformed glutathione. NAC provides cysteine, an amino-acid precursor the body can use to produce glutathione.

Is Liposomal Glutathione the same as NAC + Glycine?

No.

NAC + Glycine supplies two amino-acid precursors used in internal glutathione synthesis. Liposomal Glutathione provides reduced glutathione directly.

Which is better: Liposomal Glutathione or NAC + Glycine?

Neither option is universally better.

Liposomal Glutathione may be preferred for direct supplementation and softgel convenience. NAC + Glycine may be preferred for precursor support, a vegan formula and the additional nutritional roles of NAC and glycine.

Can I take Liposomal Glutathione with NAC + Glycine?

They may be combined under professional guidance, but using both may be unnecessary for many customers.

Review the complete antioxidant routine before stacking multiple glutathione-focused supplements.

Can I take Liposomal Glutathione with Nrf2 Detox?

Nrf2 Detox supports the body’s endogenous antioxidant-response pathways, while Liposomal Glutathione supplies glutathione directly.

The products may complement one another, but the combination creates a more intensive antioxidant and detoxification-focused routine. Professional guidance is appropriate for regular combined use.

Can I take it with O.N.E. Multivitamin?

Yes. O.N.E. Multivitamin provides foundational vitamins, minerals and antioxidants, while Liposomal Glutathione supplies targeted glutathione support.

Can I take it with O.N.E. Omega?

Yes. Omega-3 fatty acids and glutathione support different aspects of cellular, cardiovascular and healthy-aging wellness.

Can I take it with Ubiquinol-QH?

Yes. Ubiquinol supports mitochondrial energy and antioxidant activity, while glutathione supports broader cellular antioxidant and detoxification systems.

Can I take Liposomal Glutathione with magnesium?

Yes. Magnesium and glutathione serve different nutritional functions and can generally be used within the same routine.

Can I take it with creatine?

Yes. Creatine supports cellular energy, muscle strength and exercise performance, while glutathione supports antioxidant defenses and cellular protection.

Can I take it with Probiotic-5?

Yes. Probiotic-5 supports intestinal microflora, while Liposomal Glutathione supports antioxidant and liver function.

Can I take it with Berberine UltraSorb?

They may be included within the same healthy-aging or metabolic routine.

Customers taking medications or managing glucose, liver or cardiovascular conditions should have the full combination reviewed professionally.

Is Liposomal Glutathione vegan?

No. The softgel contains gelatin and beeswax.

Is Liposomal Glutathione vegetarian?

No. The gelatin softgel makes it unsuitable for vegetarian diets.

Does Liposomal Glutathione contain soy?

Yes. The phospholipid complex is derived from soy, and the label states that the product contains soy.

People with a soy allergy should not assume this product is appropriate.

Does it contain dairy?

Dairy is not listed as an ingredient.

Customers with severe allergies should inspect the current physical label before use.

Is it gluten-free?

Gluten is not listed as an ingredient, and Pure Encapsulations identifies gluten among the unnecessary additives and common allergens excluded from its general formulations.

Customers with severe sensitivities should always confirm the current packaging.

Is Liposomal Glutathione non-GMO?

Yes. It is identified as GMO-free.

Where does the glutathione come from?

The glutathione is produced through corn-glucose fermentation.

Does it contain corn?

The glutathione is sourced through corn-glucose fermentation.

Customers with a severe corn allergy should consult the manufacturer or a healthcare professional regarding suitability.

Does Liposomal Glutathione require refrigeration?

No. The softgel formula is shelf-stable.

Store it in a cool, dry place away from excessive heat and moisture.

Can I travel with it?

Yes. The shelf-stable softgels are convenient for travel.

Avoid leaving the bottle in a hot vehicle, direct sunlight or another location exposed to excessive heat.

Is this the same as Pure Encapsulations Liposomal Glutathione liquid?

No. The liquid and softgel products are separate formulas with different ingredients and directions.

This listing is for the Liposomal Glutathione softgels containing 250 mg of glutathione per capsule.

Can glutathione cause side effects?

Glutathione is generally well tolerated, but possible effects may include:

• Digestive discomfort

• Nausea

• Bloating

• Loose stools

• Headache

• Sensitivity to an ingredient in the softgel

Discontinue use and seek professional guidance if significant or persistent symptoms develop.

Can people with asthma take glutathione?

People with asthma or another chronic respiratory condition should consult a healthcare professional before beginning a concentrated glutathione supplement.

Can people with liver disease use Liposomal Glutathione?

Customers with liver disease, abnormal liver tests or a history of significant alcohol use should consult the healthcare professional managing their condition.

A liver-support supplement should not replace appropriate testing or treatment.

Can people with kidney disease take it?

Customers with kidney disease or reduced kidney function should consult their healthcare professional before adding concentrated antioxidant supplements.

Can Liposomal Glutathione be taken during cancer treatment?

Antioxidant supplements may not be appropriate with every chemotherapy, radiation or immunotherapy treatment.

Customers undergoing cancer treatment should obtain approval from their oncology team before use.

Does glutathione interact with medications?

Glutathione does not have the same extensive interaction profile as many herbs, but individual medications and medical conditions vary.

Customers taking prescription medication should have the product reviewed by a pharmacist or healthcare professional.

Can pregnant customers take Liposomal Glutathione?

Pregnant customers should consult their healthcare professional before use.

Can nursing customers take Liposomal Glutathione?

Breastfeeding customers should obtain professional guidance before using a concentrated glutathione supplement.

Can children take Pure Encapsulations Liposomal Glutathione?

The product is intended for adults ages 18 and older.

A pediatrician should determine whether glutathione supplementation is appropriate for a child or teenager.

Who should consult a healthcare professional before use?

Professional guidance is especially important for customers who:

• Are pregnant or nursing

• Have a soy allergy

• Take prescription medication

• Have liver or kidney disease

• Have asthma or another respiratory condition

• Are receiving chemotherapy, radiation or immunotherapy

• Have an upcoming surgical procedure

• Have a diagnosed medical condition

• Are under 18 years old

How should Liposomal Glutathione be stored?

Store the bottle tightly closed in a cool, dry place away from direct sunlight, excessive heat and moisture.

Refrigeration is not required.

Keep out of reach of children.

Five-Strain Probiotic Support for Gut Health, Digestive Comfort and Immune Wellness

Support a balanced intestinal microbiome with Pure Encapsulations Probiotic-5, a broad-spectrum probiotic formula providing 10 billion colony-forming units from five carefully selected bacterial strains in every capsule.

The digestive tract is home to trillions of microorganisms that influence digestion, nutrient metabolism, intestinal-barrier function and immune activity. Diet, stress, travel, illness, medications and changes in routine can all affect the balance of this complex microbial community.

Probiotic-5 combines researched strains of Lactobacillus and Bifidobacterium to support healthy intestinal microflora, gastrointestinal comfort and the protective mucosal lining of the digestive tract. The dairy-free and soy-free formula is grown on a specialized plant-based medium and delivered in a convenient vegetarian capsule.

Whether you are building a foundational digestive-health routine or looking for targeted daily microbiome support, Probiotic-5 provides a straightforward five-strain formula without an unnecessarily high capsule count.

Benefits of Probiotic-5

Probiotic-5 supports:

• Healthy intestinal microflora

• A balanced gut environment

• Gastrointestinal comfort

• Healthy intestinal-barrier function

• The protective mucosal lining of the digestive tract

• Normal digestion and nutrient utilization

• Healthy immune-system function

• Normal immune-cell activity

• Healthy yeast balance

• Digestive resilience during changes in diet or routine

• Long-term gut and digestive wellness

10 Billion CFU per Capsule

Each vegetarian capsule provides 10 billion colony-forming units, commonly abbreviated as CFU.

CFU is a measurement used to estimate the number of viable microorganisms in a probiotic product. While the total CFU count is important, the identity and quality of the individual strains are equally relevant.

Probiotic-5 combines five identified strains rather than using an unspecified bacterial blend.

Five Identified Probiotic Strains

Each capsule contains the following probiotic strains:

• Bifidobacterium lactis Bl-04

• Lactobacillus acidophilus La-14

• Lactobacillus rhamnosus Lr-32

• Bifidobacterium longum Bl-05

• Bifidobacterium bifidum Bb-06

These Lactobacillus and Bifidobacterium strains provide broad support across different regions of the gastrointestinal tract.

Lactobacillus acidophilus La-14

Lactobacillus acidophilus is commonly found within the intestinal and gastrointestinal environment.

The La-14 strain helps support:

• Healthy intestinal microflora

• Digestive comfort

• Normal microbial balance

• Healthy immune responses within the gastrointestinal tract

Lactobacillus rhamnosus Lr-32

Lactobacillus rhamnosus is a widely used probiotic species associated with intestinal and immune wellness.

The Lr-32 strain supports:

• Healthy gut ecology

• Intestinal-barrier function

• Normal immune-system activity

• Digestive resilience during everyday challenges

Bifidobacterium lactis Bl-04

Bifidobacterium lactis is frequently included in broad-spectrum probiotic formulas because of its role in intestinal and immune health.

The Bl-04 strain supports:

• Healthy intestinal flora

• Gastrointestinal-barrier integrity

• Normal immune-cell function

• A balanced digestive environment

Bifidobacterium longum Bl-05

Bifidobacterium longum is naturally associated with the human gastrointestinal tract and is commonly found in the colon.

The Bl-05 strain supports:

• Healthy microbial diversity

• Digestive comfort

• A balanced intestinal environment

• Normal immune signaling within the gastrointestinal tract

Bifidobacterium bifidum Bb-06

Bifidobacterium bifidum contributes to microbial balance and supports the normal function of the intestinal lining.

The Bb-06 strain supports:

• Healthy gut ecology

• Mucosal-barrier health

• Digestive comfort

• Normal immune defenses

Support for a Healthy Gut Microbiome

The gut microbiome consists of bacteria and other microorganisms living throughout the digestive tract.

A healthy intestinal ecosystem helps support:

• Normal digestion

• Nutrient processing

• Production of certain microbial metabolites

• Intestinal-barrier integrity

• Immune-system communication

• Protection against excessive growth of less desirable organisms

Probiotic-5 introduces five beneficial bacterial strains to complement the microorganisms already present within the digestive tract.

A probiotic supplement works best alongside habits that nourish the microbiome, including adequate fiber, diverse plant foods, regular movement, sufficient hydration and consistent sleep.

Intestinal-Barrier Support

The intestinal lining forms an important boundary between the contents of the digestive tract and the rest of the body.

A healthy intestinal barrier helps regulate which nutrients and compounds are absorbed while supporting protection from undesirable substances. The mucosal layer covering the intestinal lining also provides an environment where beneficial microbes can interact with the digestive and immune systems.

Probiotic-5 supports gastrointestinal-barrier function by helping maintain:

• Healthy intestinal microflora

• The protective mucosal lining

• Normal epithelial integrity

• Balanced immune activity within the gut

Digestive Comfort and Regularity

Digestive comfort depends on many factors, including food choices, fiber intake, hydration, stress, physical activity and the composition of the intestinal microbiome.

Probiotic-5 supports a balanced microbial environment that can contribute to normal digestive function and gastrointestinal comfort.

It may be a useful addition for adults experiencing occasional changes related to:

• Travel

• Dietary transitions

• Changes in routine

• Periods of increased stress

• Reduced intake of fermented foods

• General microbiome imbalance

Persistent abdominal pain, unexplained weight loss, blood in the stool, severe diarrhea or ongoing changes in bowel habits should be medically evaluated.

Probiotic Support for Immune Health

A significant amount of immune activity occurs in and around the gastrointestinal tract.

Beneficial intestinal bacteria interact with immune cells and the intestinal lining, helping support normal immune recognition, signaling and defensive responses.

Probiotic-5 supports:

• Normal gastrointestinal immune function

• Healthy B-cell, T-cell and natural-killer-cell activity

• Balanced cytokine production

• Intestinal-barrier defenses

• Overall immune wellness

Probiotic-5 is not intended to prevent or treat infections. It should complement foundational immune habits such as adequate sleep, balanced nutrition, regular exercise and appropriate preventive healthcare.

Healthy Yeast Balance

A balanced intestinal microbiome helps create an environment where beneficial bacteria and other microorganisms coexist appropriately.

The Lactobacillus and Bifidobacterium strains in Probiotic-5 support healthy intestinal flora and normal yeast balance.

This product is not an antifungal medication and should not be used to self-treat a suspected yeast infection, oral thrush or another fungal condition.

Dairy-Free and Soy-Free Probiotic Strains

All five probiotic strains are grown on a dairy-free and soy-free medium, making Probiotic-5 suitable for customers who avoid these ingredients.

The formula is also:

• Vegetarian

• Gluten-free

• GMO-free

• Dairy-free

• Soy-free

• Free from artificial colors and sweeteners

• Free from unnecessary binders and preservatives

• Free from magnesium stearate

People with severe allergies should always inspect the current product label before use.

Protective Rice-Starch Technology

Probiotic organisms are sensitive to factors such as heat, moisture, oxygen and stomach conditions.

Probiotic-5 includes a specialized rice starch produced through a natural enzymatic process. This protective material helps maintain the viability of the probiotic organisms within the formula.

Refrigeration remains necessary to preserve culture viability throughout storage.

Probiotic-5 and Healthy Aging

Digestive and immune wellness become increasingly important throughout adulthood.

A healthy microbiome supports nutrient processing, gastrointestinal-barrier integrity and normal immune function—all of which contribute to long-term resilience and quality of life.

Probiotic-5 can complement a healthy-aging routine that includes:

• A fiber-rich diet

• Adequate protein

• Diverse fruits and vegetables

• Regular physical activity

• Consistent sleep

• Stress management

• Appropriate hydration

• Limited unnecessary antibiotic exposure

• Routine medical care

Product Highlights

• 10 billion CFU per capsule

• Five identified probiotic strains

• Lactobacillus and Bifidobacterium blend

• Supports healthy intestinal microflora

• Supports gastrointestinal comfort

• Supports intestinal-barrier integrity

• Supports the protective mucosal lining

• Supports healthy immune function

• Supports normal yeast balance

• Dairy-free growing medium

• Soy-free growing medium

• 60 vegetarian capsules per bottle

• Suitable for adults ages 18 and older

• Vegetarian

• Gluten-free

• GMO-free

• Dairy-free

• Soy-free

• Free from artificial colors and sweeteners

• Free from unnecessary binders, fillers and preservatives

• Requires refrigeration

Probiotic Strains per Capsule

Each vegetarian capsule provides a total of 10 billion CFU from:

• Bifidobacterium lactis Bl-04

• Lactobacillus acidophilus La-14

• Lactobacillus rhamnosus Lr-32

• Bifidobacterium longum Bl-05

• Bifidobacterium bifidum Bb-06

Other ingredients include hypoallergenic plant fiber and a vegetarian capsule made from cellulose and water.

Suggested Use

Take one capsule one to two times daily, with or between meals.

The capsule may be taken:

• With breakfast

• Between breakfast and lunch

• With another meal

• At a consistent time that fits your daily routine

Consistency is generally more important than taking the capsule at one precise hour.

Storage

Keep refrigerated to maintain culture viability.

Keep the bottle tightly closed and protect it from excessive heat and moisture. Refrigerate promptly after purchase and return the bottle to the refrigerator after each use.

Frequently Asked Questions

What is Pure Encapsulations Probiotic-5?

Probiotic-5 is a broad-spectrum probiotic supplement containing five identified Lactobacillus and Bifidobacterium strains.

Each vegetarian capsule provides 10 billion CFU to support healthy intestinal microflora, digestive comfort, gastrointestinal-barrier function and immune wellness.

How many probiotic strains are in Probiotic-5?

The formula contains five probiotic strains:

• Bifidobacterium lactis Bl-04

• Lactobacillus acidophilus La-14

• Lactobacillus rhamnosus Lr-32

• Bifidobacterium longum Bl-05

• Bifidobacterium bifidum Bb-06

How many CFU are in each capsule?

Each capsule provides 10 billion colony-forming units.

What does CFU mean?

CFU stands for colony-forming units.

It is a measurement used to estimate the number of viable microorganisms contained in a probiotic product.

Is a higher CFU count always better?

No. A higher number is not automatically better for every person.

The specific bacterial strains, product quality, storage conditions, individual digestive needs and consistency of use are also important.

Why are the strain numbers important?

Strain numbers identify the specific version of a probiotic species.

Different strains within the same bacterial species can have different characteristics, which is why a label listing the complete strain identification provides more useful information than one listing only the general species.

What does Probiotic-5 support?

Probiotic-5 supports:

• Healthy gut flora

• Digestive comfort

• Intestinal-barrier function

• The protective mucosal lining

• Healthy yeast balance

• Normal immune-system activity

Is Probiotic-5 good for general gut health?

Yes. It is designed as a broad-spectrum daily probiotic for adults seeking foundational intestinal and digestive support.

Can Probiotic-5 help with bloating?

A balanced intestinal microbiome can support digestive comfort, but bloating has many potential causes, including food intolerances, constipation, rapid eating and gastrointestinal conditions.

Probiotic-5 is not guaranteed to eliminate bloating. Persistent or severe bloating should be evaluated by a healthcare professional.

Can Probiotic-5 help with regularity?

Probiotics can support a healthy digestive environment, which may contribute to normal bowel function.

Adequate fiber, hydration, movement and balanced nutrition remain important for regularity.

Can Probiotic-5 be used for constipation?

It may support general gastrointestinal health, but it is not a laxative or treatment for chronic constipation.

Persistent constipation, pain or major changes in bowel habits should be professionally evaluated.

Can Probiotic-5 be used for diarrhea?

Probiotic effects on diarrhea vary according to the cause and the specific strains used.

Severe, persistent or bloody diarrhea, especially when accompanied by fever or dehydration, requires medical care.

Can Probiotic-5 treat irritable bowel syndrome?

No. Probiotic-5 is not intended to diagnose or treat irritable bowel syndrome.

People with IBS may respond differently to individual probiotic strains and should work with a qualified healthcare professional when symptoms are ongoing.

Does Probiotic-5 support the intestinal barrier?

Yes. The formula supports healthy gastrointestinal-barrier function and the mucosal lining of the digestive tract.

Does Probiotic-5 support immunity?

Yes. Beneficial intestinal bacteria interact with immune cells and support normal immune activity within the gastrointestinal tract.

The product does not prevent or treat infections.

Does Probiotic-5 support healthy yeast balance?

Yes. Maintaining healthy intestinal flora helps support a balanced microbial environment, including normal yeast balance.

It is not an antifungal medication.

How many capsules should I take?

Take one capsule one to two times daily.

Follow individualized instructions from a qualified healthcare professional when they differ from the product label.

Can I take two capsules together?

The label allows one capsule one to two times daily.

Dividing two capsules between different times of day may be more convenient for some customers, but follow professional guidance when using probiotics for a specific health concern.

Should Probiotic-5 be taken with food?

It may be taken with or between meals.

Choose the timing that is easiest to follow consistently and provides the best digestive tolerance.

What is the best time to take a probiotic?

There is no single time that is best for everyone.

Breakfast, another meal or a consistent time between meals can all work. Regular daily use and correct storage are more important than choosing one exact hour.

Can I take Probiotic-5 at night?

Yes. It may be taken in the evening with or between meals.

Can I take Probiotic-5 every day?

Yes. It is formulated for daily use by adults when appropriate for their health needs.

How long does Probiotic-5 take to work?

Responses vary.

Some customers notice digestive changes within days, while broader microbiome or comfort-related benefits may require several weeks of consistent use. Diet, stress, medications and baseline gut health can all affect the response.

Should I expect gas when beginning a probiotic?

Some people notice temporary gas, bloating or changes in bowel habits when beginning a probiotic.

These effects are often mild. Reduce use and seek professional guidance if symptoms are significant, persistent or worsening.

Can a probiotic upset my stomach?

Probiotics may occasionally cause gas, bloating, abdominal discomfort or changes in stool frequency.

Starting with one capsule daily may help assess individual tolerance.

Does Probiotic-5 require refrigeration?

Yes. Probiotic-5 must be refrigerated to maintain culture viability.

What happens if Probiotic-5 is left out of the refrigerator?

Heat and prolonged room-temperature storage can reduce probiotic viability.

Return the bottle to refrigeration as soon as possible. Contact Panther Longevity when there are concerns about extended exposure to heat or improper storage.

Can I travel with Probiotic-5?

Yes, but maintain refrigeration as consistently as practical.

An insulated medication or food cooler can help protect the product during travel. Avoid leaving it in a hot vehicle, direct sunlight or checked luggage exposed to high temperatures.

How many capsules are in each bottle?

Each bottle contains 60 vegetarian capsules.

At one capsule daily, one bottle provides a 60-day supply. At two capsules daily, it provides a 30-day supply.

Is Probiotic-5 vegetarian?

Yes. It uses a plant-based cellulose capsule and is suitable for vegetarian diets.

Is Probiotic-5 vegan?

The listed ingredients are plant-based, but customers following a strict vegan lifestyle should review the current physical label for source confirmation.

Is Probiotic-5 dairy-free?

Yes. The five strains are grown on a dairy-free medium, and the finished formula is dairy-free.

Is Probiotic-5 soy-free?

Yes. The probiotic strains are grown on a soy-free medium, and the finished formula is soy-free.

Is Probiotic-5 gluten-free?

Yes. It is gluten-free.

Is Probiotic-5 non-GMO?

Yes. It is GMO-free.

Does Probiotic-5 contain prebiotics?

It is primarily a probiotic formula.

The protective rice starch helps preserve organism viability but should not be treated as a significant dietary prebiotic or fiber supplement.

What is the difference between probiotics and prebiotics?

Probiotics are beneficial live microorganisms.

Prebiotics are fibers or other compounds that beneficial intestinal microbes can use as nourishment.

A complete gut-health routine may include both probiotic organisms and adequate prebiotic fiber from foods or supplements.

Can I take Probiotic-5 with PureLean Fiber?

Yes. A probiotic and fiber supplement can complement one another within a digestive-health routine.

Begin gradually and maintain adequate hydration because increasing fiber intake too quickly may cause gas or bloating.

Can I take Probiotic-5 with Berberine UltraSorb?

They may be used in the same broader gut and metabolic-health routine, but berberine has biological activity within the gastrointestinal tract.

Customers using berberine for a diagnosed digestive or metabolic condition should have the combination reviewed professionally.

Can I take Probiotic-5 with Magnesium Glycinate?

Yes. Magnesium and probiotics provide different types of nutritional support and can generally be included within the same routine.

Can I take Probiotic-5 with O.N.E. Multivitamin?

Yes. A multivitamin provides foundational micronutrients, while Probiotic-5 supplies targeted intestinal microflora support.

Can I take Probiotic-5 with NAC + Glycine?

Yes. Probiotic-5 supports intestinal and immune wellness, while NAC + Glycine supports glutathione production and antioxidant defenses.

Can I take Probiotic-5 with other probiotics?

Combining several probiotics may create unnecessary strain and CFU overlap.

Use multiple probiotic products together only when there is a clear reason or professional recommendation.

Can I take Probiotic-5 with fermented foods?

Yes. Yogurt, kefir, sauerkraut, kimchi and other fermented foods can be included in the same diet when tolerated.

A probiotic supplement does not replace a diverse, fiber-rich eating pattern.

Can I take Probiotic-5 while taking antibiotics?

Ask the prescribing healthcare professional or pharmacist about appropriate use and timing.

Antibiotics can affect probiotic bacteria, and the ideal separation period depends on the specific medication and treatment plan.

Should I continue Probiotic-5 after finishing antibiotics?

Some people use probiotics after antibiotic treatment to support intestinal microflora, but the appropriate product and duration vary.

Follow guidance from the healthcare professional managing the antibiotic treatment.

Does Probiotic-5 interact with medications?

Probiotics do not have the same interaction profile as many herbs or minerals, but they may be inappropriate for certain medically vulnerable individuals.

Anyone taking medication for a serious condition should review the product with a healthcare professional.

Can pregnant or nursing customers take Probiotic-5?

Pregnant or nursing customers should consult their healthcare professional before beginning a new probiotic supplement.

Can children take Probiotic-5?

This formula is intended for adults ages 18 and older.

A pediatrician should select an age-appropriate probiotic and serving for children or teenagers.

Can immunocompromised customers take Probiotic-5?

Probiotics may be contraindicated for immunocompromised individuals because live microorganisms can present additional risks.

Customers with a weakened immune system, a serious illness or immunosuppressive treatment should not use Probiotic-5 without direct medical approval.

Who should consult a healthcare professional before use?

Professional guidance is especially important for customers who:

• Are pregnant or nursing

• Are immunocompromised

• Are seriously ill or hospitalized

• Take immunosuppressive medication

• Have a central venous catheter

• Are receiving cancer treatment

• Have recently undergone major surgery

• Take prescription medication

• Have persistent or severe digestive symptoms

• Are under 18 years old

How should Probiotic-5 be stored?

Keep the bottle refrigerated with the cap tightly closed.

Protect it from heat, moisture and direct sunlight, and keep it out of reach of children.

Enhanced-Absorption Berberine for Glucose Metabolism, Cardiometabolic Health and Weight-Management Support

Support healthy glucose metabolism and overall metabolic wellness with Pure Encapsulations Berberine UltraSorb™, an advanced berberine supplement featuring enhanced-absorption Phytosome™ technology.

Each vegan capsule provides 550 mg of Berbevis® berberine phytosome, a specialized complex made from Berberis aristata root extract and sunflower-derived phospholipids. This delivery system improves the absorption of berberine, a plant compound that is ordinarily difficult for the body to absorb.

Berberine UltraSorb supports healthy insulin-receptor function, glucose metabolism, lipid metabolism and cellular energy regulation. It is an excellent addition to a comprehensive metabolic-health routine that includes balanced nutrition, regular exercise, resistance training, quality sleep and healthy body-composition habits.

Unlike conventional berberine formulas that may require larger daily amounts, Berberine UltraSorb uses clinically studied phytosome technology to provide greater bioavailability in a convenient one-capsule serving.

Benefits of Berberine UltraSorb

Berberine UltraSorb supports:

• Healthy glucose metabolism

• Healthy blood-glucose levels already within the normal range

• Normal insulin-receptor function and signaling

• Healthy insulin sensitivity

• Cardiometabolic wellness

• Healthy cholesterol and triglyceride metabolism

• Cellular energy regulation

• Normal AMPK activity

• Healthy endothelial and vascular function

• Metabolic flexibility

• Weight-management efforts as part of a healthy lifestyle

• Long-term metabolic health and healthy aging

Enhanced-Absorption Berberine Phytosome

Standard berberine has naturally low intestinal absorption. This means that only a small amount of conventional berberine may reach circulation after it is taken.

Berberine UltraSorb addresses this limitation with Berbevis® Phytosome™ technology. The formula combines berberine with sunflower-derived phospholipids to improve its solubility, dispersion and movement across intestinal membranes.

This enhanced-delivery system has demonstrated approximately four times greater bioavailability than standard berberine in a human pharmacokinetic study.

Improved absorption may offer several advantages:

• A lower amount of material is needed per capsule

• Fewer capsules may be required

• The formula may be easier to incorporate into a daily routine

• Lower total berberine intake may improve digestive tolerance for some users

• More consistent absorption may support reliable daily supplementation

550 mg of Berbevis® per Capsule

Each vegan capsule provides:

• 550 mg of Berbevis® berberine phytosome

• Standardization to 28% berberine

• Berberine derived from Berberis aristata root

• Sunflower-derived phospholipids

• Approximately 154 mg of standardized berberine within the complete phytosome complex

The 550 mg amount refers to the entire Berbevis® phytosome complex, not 550 mg of isolated berberine hydrochloride.

Because the phytosome complex has enhanced absorption, it should not be directly compared milligram-for-milligram with standard berberine hydrochloride products.

Support for Healthy Glucose Metabolism

Glucose is a primary source of energy for the body. After carbohydrates are digested, glucose enters the bloodstream and is transported into cells where it can be used or stored.

Insulin helps regulate this process by signaling cells to take in glucose. Maintaining healthy insulin signaling and glucose metabolism is important for:

• Stable everyday energy

• Metabolic flexibility

• Healthy body composition

• Cardiovascular wellness

• Long-term cellular health

• Healthy aging

Berberine supports insulin-receptor expression and signaling, helping cells respond appropriately to insulin. It also supports glucose uptake and utilization through pathways associated with cellular energy regulation.

Berberine UltraSorb is intended to help maintain glucose levels already within a healthy range. It is not a replacement for diabetes medication or professional treatment for abnormal blood sugar.

AMPK and Cellular Energy Regulation

Berberine supports the activation of AMP-activated protein kinase, commonly known as AMPK.

AMPK acts as a cellular energy sensor. It helps cells respond when energy availability changes and participates in the regulation of:

• Glucose uptake

• Fatty-acid metabolism

• Mitochondrial activity

• Insulin signaling

• Cellular energy balance

• Cardiovascular function

Because AMPK influences several metabolic pathways, it is sometimes described as a metabolic master switch.

Supporting normal AMPK activity may help the body manage energy more efficiently, but berberine does not replace exercise, calorie control or a balanced diet.

Cardiometabolic Health

Cardiometabolic health refers to the relationship between cardiovascular function and metabolic factors such as blood glucose, insulin signaling, cholesterol, triglycerides, blood pressure and body composition.

Berberine UltraSorb supports several areas of cardiometabolic wellness, including:

• Healthy glucose metabolism

• Normal insulin signaling

• Healthy lipid and triglyceride metabolism

• Endothelial function

• Healthy blood flow

• Cellular energy regulation

It works best alongside foundational cardiovascular habits such as:

• Regular resistance and cardiovascular exercise

• A fiber-rich, nutrient-dense diet

• Healthy body-composition management

• Adequate sleep

• Stress management

• Appropriate blood-pressure monitoring

• Avoiding tobacco

• Routine medical screening

Cholesterol and Triglyceride Metabolism

Berberine supports the biological pathways involved in healthy cholesterol and triglyceride metabolism.

This makes Berberine UltraSorb a useful option for adults who want broad cardiometabolic support rather than a glucose-focused supplement alone.

The product is intended to help maintain lipid levels already within a healthy range. It should not replace statins, fibrates or other medications prescribed to manage abnormal cholesterol or triglycerides.

Customers with elevated lipid levels should continue laboratory monitoring and follow their healthcare professional’s treatment plan.

Berberine and Weight-Management Support

Berberine has become popular within weight-management and metabolic-health routines because of its effects on glucose regulation, insulin signaling, lipid metabolism and AMPK activity.

Berberine UltraSorb may complement a healthy weight-management program by supporting:

• Metabolic function

• Healthy glucose utilization

• Insulin sensitivity

• Lipid metabolism

• Cellular energy regulation

• Healthy body-composition efforts

However, berberine is not a fat burner and does not produce significant weight loss on its own.

The strongest weight-management program includes:

• An appropriate calorie intake

• Adequate dietary protein

• Resistance training

• Regular daily movement

• Cardiovascular exercise

• Sufficient fiber

• Consistent sleep

• Stress management

• Long-term behavioral consistency

Research on berberine and body weight is promising but remains inconsistent. Results vary according to the formulation, amount used, duration, baseline metabolic health and lifestyle.

Berberine Is Not “Natural Ozempic”

Berberine is sometimes called “nature’s Ozempic” online, but this comparison is misleading.

Berberine and prescription GLP-1 medications are not the same. They have different mechanisms, strengths, evidence, dosing requirements and clinical uses.

Berberine UltraSorb:

• Is a dietary supplement

• Does not contain semaglutide or tirzepatide

• Is not a GLP-1 medication

• Does not produce the same expected degree of weight loss

• Should not replace prescribed diabetes or weight-management treatment

• Does not require injection

• Supports metabolic pathways through different mechanisms

Customers using a GLP-1 medication should consult their prescribing healthcare professional before adding berberine because the combination may further influence blood glucose or digestive function.

Metabolic Support During a Weight-Loss Program

Calorie restriction can create metabolic and nutritional challenges, particularly when a plan lacks sufficient protein, resistance training or dietary quality.

Berberine UltraSorb can support a structured weight-management routine, but it should be combined with habits that preserve muscle and long-term health.

A complete program should prioritize:

• Adequate protein at each meal

• Resistance training two or more times per week

• Fiber-rich foods

• Hydration

• Nutrient-dense carbohydrates

• Healthy fats

• Sustainable calorie control

• Regular body-composition monitoring

The goal should be to improve body composition and metabolic health—not simply reduce scale weight.

Berberine and Healthy Aging

Metabolic health is a central component of healthy aging.

Maintaining healthy glucose regulation, insulin sensitivity, cardiovascular function and body composition can support energy, mobility and long-term physical resilience.

Berberine UltraSorb fits naturally into a longevity-focused routine designed to support:

• Metabolic flexibility

• Healthy glucose regulation

• Cardiovascular wellness

• Cellular energy balance

• Healthy lipid metabolism

• Healthy body composition

• Long-term physical function

It pairs well with other foundational healthy-aging products such as:

• O.N.E. Multivitamin

• O.N.E. Omega

• Magnesium Glycinate

• Ubiquinol-QH

• Creatine

• Protein powder

• Fiber supplements

Individual supplement combinations should reflect diet, health history, medications and laboratory results.

Berberine and Digestive Health

Berberine is a plant alkaloid with biological activity in the digestive tract, and it has a long history of use in traditional wellness practices.

Berberine UltraSorb may complement a broader digestive-health routine, but it should not be marketed as a general probiotic or as a treatment for infections, small intestinal bacterial overgrowth, inflammatory bowel disease or other gastrointestinal conditions.

Customers experiencing persistent digestive symptoms should seek professional evaluation before using concentrated berberine.

Vegan, Gluten-Free Metabolic Support

Berberine UltraSorb is made with vegan ingredients and a plant-based capsule.

The phytosome uses sunflower lecithin rather than soy-derived phospholipids. The complete formula also contains pea protein isolate, grape-seed extract and plant-derived cellulose as components of the delivery system.

Product Highlights

• 550 mg of Berbevis® berberine phytosome per capsule

• Standardized to contain 28% berberine

• Enhanced-absorption Phytosome™ technology

• Approximately four times more bioavailable than standard berberine

• Supports healthy glucose metabolism

• Supports healthy insulin-receptor function

• Supports normal AMPK activity

• Supports healthy lipid and triglyceride metabolism

• Supports cardiometabolic wellness

• Supports weight-management efforts within a healthy lifestyle

• Convenient one-capsule serving

• 60 capsules per bottle

• Vegan and vegetarian

• Certified gluten-free

• GMO-free

• Soy-free finished formula

• Dairy-free

• Free from artificial colors and sweeteners

• Free from unnecessary binders, fillers and preservatives

• Free from magnesium stearate

Ingredients

Each vegan capsule provides:

Berbevis® Berberine–Indena Phytosome™ Complex — 550 mg

The complex contains berberine from Berberis aristata root extract and sunflower-derived phospholipids and is standardized to contain 28% berberine.

Other components of the phytosome complex include pea protein isolate, sunflower lecithin, grape-seed extract, cellulose and silicon dioxide.

Additional ingredients include a vegetarian capsule made from cellulose and water, hypoallergenic plant fiber and ascorbyl palmitate.

Suggested Use

Take one capsule one to two times daily, with or between meals.

Customers new to berberine may prefer to begin with one capsule daily to evaluate digestive tolerance.

The most appropriate timing may depend on individual goals, meal patterns, medications and healthcare guidance.

Do not exceed the suggested serving unless directed by a qualified healthcare professional.

Berberine UltraSorb should not be taken during pregnancy or while breastfeeding.

Frequently Asked Questions

What is Pure Encapsulations Berberine UltraSorb?

Berberine UltraSorb is an enhanced-absorption berberine supplement formulated to support glucose metabolism, insulin signaling, cardiometabolic health and healthy lipid metabolism.

It contains Berbevis® berberine phytosome, which combines berberine with sunflower-derived phospholipids to improve absorption.

How much Berberine UltraSorb is in each capsule?

Each capsule provides 550 mg of Berbevis® berberine phytosome.

The complete complex is standardized to contain 28% berberine.

Does each capsule contain 550 mg of pure berberine?

No. The 550 mg amount refers to the complete Berbevis® phytosome complex, including berberine and the phospholipid delivery system.

At 28% standardization, each capsule contains approximately 154 mg of berberine within the enhanced-absorption complex.

Why does Berberine UltraSorb contain less berberine than some standard formulas?

Standard berberine is poorly absorbed and is often taken in larger amounts.

Berberine UltraSorb uses Phytosome™ technology that has demonstrated approximately four times greater bioavailability than standard berberine. The enhanced-delivery system is designed to improve absorption without requiring the same high amount of conventional berberine hydrochloride.

What is Berbevis®?

Berbevis® is a clinically studied berberine phytosome made from Berberis aristata root extract and sunflower-derived phospholipids.

It is designed to improve the solubility, stability and absorption of berberine.

What is Phytosome™ technology?

Phytosome technology combines a botanical compound with phospholipids.

The phospholipids help protect the plant compound during digestion and improve its ability to disperse and move across intestinal membranes.

Is Berberine UltraSorb better absorbed than regular berberine?

Yes. The Berbevis® phytosome used in Berberine UltraSorb demonstrated approximately four times greater bioavailability than standard berberine in a human pharmacokinetic study.

What does berberine do?

Berberine supports glucose metabolism, insulin-receptor signaling, AMPK activity, lipid metabolism and cellular energy regulation.

It is commonly used within metabolic, cardiovascular and weight-management wellness routines.

What is AMPK?

AMPK, or AMP-activated protein kinase, is an enzyme that helps cells monitor and regulate energy availability.

It participates in glucose uptake, fatty-acid metabolism, mitochondrial function and insulin signaling.

Does Berberine UltraSorb support blood sugar?

Yes. It supports healthy glucose metabolism and helps maintain blood-glucose levels already within the normal range.

It is not a treatment for diabetes and should not replace prescription medication or blood-glucose monitoring.

Does berberine improve insulin sensitivity?

Berberine supports insulin-receptor function and signaling, which are important components of healthy insulin sensitivity.

Customers with insulin resistance, prediabetes or diabetes should use berberine only with appropriate medical guidance.

Can Berberine UltraSorb be used for prediabetes?

Customers with prediabetes should consult their healthcare professional before using berberine.

Prediabetes requires a structured plan that may include nutrition changes, weight management, physical activity, laboratory monitoring and medication when appropriate.

Can people with diabetes take Berberine UltraSorb?

Berberine can affect glucose metabolism and may increase the effects of diabetes medications.

Customers with diabetes should not begin Berberine UltraSorb without guidance from the clinician managing their blood glucose.

Does berberine help with weight loss?

Berberine may support weight-management efforts through its effects on glucose metabolism, insulin signaling, lipid metabolism and AMPK activity.

However, it is not a fat burner, and evidence for meaningful weight loss remains mixed. It works best as part of a calorie-controlled diet, resistance-training program and sustainable lifestyle.

Is berberine a natural alternative to Ozempic?

No. Berberine is not a natural version of Ozempic.

Ozempic contains prescription semaglutide, a GLP-1 receptor agonist. Berberine is a botanical compound with different mechanisms and a different level of clinical effect.

Can Berberine UltraSorb replace a GLP-1 medication?

No. It should not replace Ozempic, Wegovy, Mounjaro, Zepbound or another prescribed medication.

Never stop or change a prescription weight-management or diabetes treatment without consulting the prescriber.

Can I take berberine with a GLP-1 medication?

The combination may further influence blood glucose and digestive function.

Customers using semaglutide, tirzepatide or another GLP-1 medication should consult their prescribing healthcare professional before adding berberine.

Does berberine suppress appetite?

Some users may notice changes in appetite, but Berberine UltraSorb is not formulated or marketed as an appetite suppressant.

Changes in appetite can also result from improved meal composition, blood-glucose patterns, medications and other factors.

Does Berberine UltraSorb support cholesterol?

Berberine supports healthy cholesterol and lipid metabolism and can help maintain levels already within a healthy range.

It does not replace statins or other prescribed cholesterol medications.

Does berberine support triglyceride metabolism?

Yes. Berberine supports healthy triglyceride and lipid metabolism as part of its broader cardiometabolic benefits.

Does berberine support heart health?

Berberine supports cardiovascular wellness through its effects on glucose metabolism, lipid metabolism, AMPK activity, endothelial function and healthy blood flow.

It is not a treatment for cardiovascular disease.

Can I take Berberine UltraSorb with a statin?

Berberine can interact with medications and may influence lipid levels.

Customers taking a statin or another cholesterol medication should consult their prescriber or pharmacist before combining it with berberine.

How many capsules should I take?

Take one capsule one to two times daily, with or between meals.

Follow individualized guidance when provided by a qualified healthcare professional.

Should I take Berberine UltraSorb with food?

It can be taken with or between meals.

Customers who experience digestive discomfort may prefer taking it with food.

What is the best time to take Berberine UltraSorb?

The timing depends on the individual’s routine and goals.

Many customers take one capsule with breakfast or lunch. When using two capsules daily, the servings can be divided between two different times of day.

Should I take berberine before a carbohydrate-containing meal?

Some customers choose to take berberine near meals containing carbohydrates because of its metabolic positioning.

However, the label permits use with or between meals, and customers using glucose-lowering medication should follow professional guidance rather than changing timing independently.

Can I take both capsules at the same time?

The serving may be divided across the day.

Taking one capsule at two separate times may support digestive tolerance and more consistent exposure. Do not take more than directed.

How long does Berberine UltraSorb take to work?

Berberine is a nutritional supplement rather than a fast-acting stimulant.

Its effects depend on metabolic status, diet, activity, serving consistency and the outcome being measured. Changes in laboratory markers may require several weeks or months and should be assessed through appropriate testing.

Can I take Berberine UltraSorb every day?

Yes. It is formulated for daily use when appropriate for the individual.

Long-term supplementation should be reviewed with a healthcare professional, particularly when medications, blood-glucose conditions or other medical issues are involved.

How long should I take berberine?

There is no universal duration that is appropriate for everyone.

The need for continued use should be based on tolerance, health goals, laboratory results, medications and professional guidance.

Does berberine cause digestive side effects?

Berberine may cause:

• Nausea

• Abdominal discomfort

• Bloating

• Constipation

• Diarrhea

• Changes in bowel habits

Starting with one capsule daily and taking it with food may improve tolerance.

Is Berberine UltraSorb easier on the stomach than standard berberine?

The enhanced-absorption formula allows a lower total amount of berberine to be used compared with many conventional formulas, which may improve tolerance for some customers.

Individual digestive responses still vary.

Can berberine cause low blood sugar?

Berberine may lower blood glucose, particularly when combined with insulin or other glucose-lowering medications.

Symptoms such as shakiness, sweating, confusion, dizziness or unusual weakness require prompt attention.

Can berberine lower blood pressure?

Berberine may influence cardiovascular and metabolic pathways.

Customers with low blood pressure or those taking blood-pressure medication should consult a healthcare professional before use.

Can I take Berberine UltraSorb with metformin?

Do not combine berberine with metformin without approval from the clinician managing your blood glucose.

The combination may increase the risk of low blood sugar or digestive side effects and may require additional monitoring.

Can I take berberine with insulin?

Berberine may increase the glucose-lowering effects of insulin.

Customers using insulin should not take Berberine UltraSorb without direct medical supervision.

Can I take it with cholesterol medication?

Berberine can affect lipid metabolism and may interact with prescription medications.

Consult a prescriber or pharmacist before combining it with a statin, fibrate or other cholesterol medication.

Can Berberine UltraSorb interact with cyclosporine?

Yes. Berberine can interact with cyclosporine and may alter its concentration in the body.

Customers taking cyclosporine or another transplant medication should not use berberine without approval from their transplant team.

Does berberine interact with other medications?

Berberine can affect drug-metabolizing enzymes and transport proteins and may interact with prescription or over-the-counter medications.

Professional guidance is especially important for customers using:

• Diabetes medication

• Insulin

• Blood-pressure medication

• Cholesterol medication

• Anticoagulants or antiplatelet medication

• Cyclosporine or other immunosuppressants

• Medications with a narrow therapeutic range

• Multiple prescription drugs

Can I take Berberine UltraSorb with O.N.E. Multivitamin?

Yes. A multivitamin provides foundational vitamins, minerals and antioxidants, while Berberine UltraSorb provides targeted metabolic support.

Can I take it with Magnesium Glycinate?

Yes. Magnesium and berberine support different aspects of glucose metabolism, cellular energy and general wellness.

Customers taking medications for diabetes or blood pressure should have the complete supplement routine reviewed professionally.

Can I take Berberine UltraSorb with O.N.E. Omega?

Yes. Omega-3 fatty acids and berberine may complement one another within a cardiometabolic wellness routine.

Can I take it with Ubiquinol-QH?

Yes. Ubiquinol supports cellular energy and cardiovascular wellness, while berberine supports metabolic and lipid pathways.

Can I take berberine with creatine?

Yes. Creatine supports muscular energy, strength and exercise performance, while berberine supports glucose and metabolic function.

Can I take Berberine UltraSorb with PureLean Fiber?

Yes. Fiber and berberine can complement a metabolic and digestive wellness routine.

Begin cautiously because both products can affect digestion. Separate the products from medications when advised by a pharmacist or healthcare professional.

Can I take Berberine UltraSorb with probiotics?

They may generally be included within the same wellness routine.

Customers using berberine for a diagnosed digestive condition should follow a healthcare professional’s treatment plan rather than self-selecting combinations.

Does berberine kill beneficial gut bacteria?

Berberine has biological activity within the digestive tract, but its effects on the microbiome are complex.

It should not be treated as a general antimicrobial or used to self-treat a suspected infection or microbiome disorder.

Is Berberine UltraSorb suitable for gut health?

It may complement a broader digestive and metabolic wellness routine, but its primary positioning is glucose metabolism and cardiometabolic support.

For general digestive health, adequate fiber, hydration, balanced nutrition and appropriate probiotic foods remain foundational.

Is Berberine UltraSorb vegan?

Yes. The formula uses plant-derived ingredients and a vegetarian cellulose capsule.

Is it vegetarian?

Yes. It is suitable for vegetarian diets.

Is Berberine UltraSorb gluten-free?

Yes. It is certified gluten-free.

Is it soy-free?

The finished product is soy-free. The phospholipids are derived from sunflower lecithin rather than soy.

Does it contain dairy?

No dairy ingredients are listed.

Is Berberine UltraSorb non-GMO?

Yes. It is GMO-free.

Does it contain artificial colors or sweeteners?

No. It is free from artificial colors and sweeteners.

Can pregnant customers take Berberine UltraSorb?

No. Berberine UltraSorb should not be taken during pregnancy.

Can breastfeeding customers take Berberine UltraSorb?

No. It should not be used while breastfeeding.

Berberine exposure may be unsafe for infants because of potential effects on bilirubin metabolism.

Can children take Berberine UltraSorb?

No. The product is intended for adults ages 18 and older.

Berberine can be unsafe for infants and should not be given to children without direct medical supervision.

Can older adults take Berberine UltraSorb?

Older adults may use it when appropriate, but they should have the product reviewed by a healthcare professional because medication interactions and blood-glucose effects may be more relevant.

Should I stop berberine before surgery?

Tell the surgical team about every medication and supplement being used.

Follow its instructions regarding when to discontinue Berberine UltraSorb before a procedure, especially when blood glucose, blood pressure or blood clotting may be affected.

Who should consult a healthcare professional before taking Berberine UltraSorb?

Professional guidance is particularly important for customers who:

• Have diabetes or prediabetes

• Take insulin or glucose-lowering medication

• Take blood-pressure medication

• Take cholesterol medication

• Use anticoagulant or antiplatelet medication

• Take cyclosporine or another immunosuppressant

• Have liver or kidney disease

• Have chronically low blood pressure

• Have an upcoming surgical procedure

• Take several prescription medications

• Are under 18 years old

Berberine UltraSorb should not be taken during pregnancy or breastfeeding.

How should Berberine UltraSorb be stored?

Store the bottle tightly closed in a cool, dry place away from direct sunlight, excessive heat and moisture.

Keep it out of reach of children.