Enhanced-Delivery Antioxidant Support for Cellular Health, Liver Function and Healthy Aging

Strengthen your body’s natural antioxidant defenses with Pure Encapsulations Liposomal Glutathione, an advanced glutathione softgel formulated with protective phospholipids for improved stability during digestion.

Each softgel provides 250 mg of Setria® reduced glutathione and 125 mg of essential phospholipids in a 375 mg BioGlute™ liposomal complex.

Glutathione is an antioxidant produced naturally throughout the body and found in virtually every cell. It helps protect cells from free radicals, supports normal enzyme activity and participates in the liver’s natural detoxification processes.

The liposomal delivery system surrounds glutathione with phospholipids that help protect its peptide bonds from digestive degradation and support movement across intestinal membranes. This makes Liposomal Glutathione a convenient option for adults seeking direct glutathione supplementation for antioxidant protection, cellular resilience, liver wellness and healthy aging.

Benefits of Liposomal Glutathione

Liposomal Glutathione supports:

• Cellular antioxidant defenses

• Protection from oxidative stress

• Healthy cellular function

• Liver health

• Natural detoxification pathways

• Phase II conjugation processes

• Healthy oxidative status

• Normal lipid metabolism

• Mitochondrial protection

• Cellular repair and maintenance

• Long-term resilience and healthy aging

What Is Glutathione?

Glutathione is a small peptide made from three amino acids:

• Cysteine

• Glycine

• Glutamate

The body produces glutathione internally, but levels and requirements can be influenced by age, diet, physical stress, environmental exposure, alcohol intake, health status and the availability of its amino-acid building blocks.

Glutathione is concentrated in tissues with substantial metabolic or detoxification demands, including the liver. It also plays important roles in cellular defense systems throughout the body.

Glutathione contributes to:

• Neutralization of free radicals

• Recycling of other antioxidants

• Normal enzyme function

• Cellular protein synthesis

• Cell maturation and transport

• Detoxification reactions

• Protection of cellular structures

• Maintenance of normal redox balance

250 mg of Setria® Glutathione per Softgel

Each softgel provides:

BioGlute™ proprietary blend — 375 mg

Providing:

• Setria® reduced glutathione — 250 mg

• Essential phospholipid complex — 125 mg

Setria® is a high-quality reduced glutathione produced through corn-glucose fermentation.

Reduced glutathione is the active antioxidant form capable of donating electrons to help neutralize reactive compounds.

Why Use Liposomal Glutathione?

Glutathione is a peptide, which means its amino acids are connected by peptide bonds. These bonds can be affected by enzymes within the digestive tract.

Glutathione also does not move easily across cell membranes on its own.

Liposomal delivery addresses these limitations by surrounding glutathione with a phospholipid structure. Phospholipids contain both water-compatible and fat-compatible regions, allowing them to form small spherical particles known as liposomes.

The liposomal system helps:

• Protect glutathione during digestion

• Improve its dispersion within the digestive tract

• Support passage across intestinal cell membranes

• Preserve the integrity of glutathione’s peptide bonds

• Deliver glutathione in a convenient softgel format

Laboratory testing has shown greater movement across an intestinal-cell model with this liposomal formula than with a matching non-liposomal glutathione powder. Human responses may still vary.

Powerful Cellular Antioxidant Support

Normal metabolism continuously produces reactive compounds known as free radicals.

Exercise, environmental pollutants, inadequate sleep, alcohol, tobacco exposure and other physical demands can also increase oxidative stress.

Antioxidant systems help keep these reactive compounds in balance. Glutathione is especially important because it can work both directly and through glutathione-dependent enzymes.

Glutathione supports cellular protection by:

• Donating electrons to reactive compounds

• Supporting glutathione peroxidase activity

• Helping neutralize hydrogen peroxide

• Protecting cellular membranes and proteins

• Supporting normal redox balance

• Participating in the recycling of other antioxidants

Oxidative stress is a normal biological process, and antioxidants should not be viewed as eliminating every free radical. The goal is to support a healthy balance between reactive compounds and the body’s protective systems.

Glutathione Peroxidase and Hydrogen Peroxide

Hydrogen peroxide is produced during normal cellular and mitochondrial energy metabolism.

Although it also functions as a signaling molecule, excessive hydrogen peroxide can affect cellular membranes, proteins and other structures.

Glutathione serves as a co-substrate for glutathione peroxidase enzymes. These enzymes help convert hydrogen peroxide and certain lipid peroxides into less reactive compounds.

This makes glutathione an important part of the body’s internal antioxidant network.

Liver and Detoxification Support

The liver is a primary site for the processing of hormones, metabolic byproducts, medications and environmental compounds.

Glutathione is found in particularly high concentrations in liver tissue, where it contributes to antioxidant protection and Phase II detoxification.

During Phase II conjugation, glutathione can be attached to certain compounds. This process may make those compounds less reactive and easier for the body to process and eliminate.

Liposomal Glutathione supports:

• Normal liver antioxidant defenses

• Healthy Phase II conjugation

• Cellular protection within liver tissue

• Processing of normal metabolic byproducts

• Healthy detoxification pathways

• Normal hepatic lipid metabolism

This product is not a “detox cleanse” and does not remove every toxin from the body. It supports the liver’s existing biological processes.

What Does Detoxification Support Mean?

Detoxification is an ongoing physiological process carried out primarily by the liver, kidneys, digestive tract, lungs and other tissues.

Effective detoxification depends on more than one supplement. It also requires:

• Adequate protein and amino acids

• Sufficient dietary fiber

• Regular bowel movements

• Hydration

• Healthy kidney and liver function

• Appropriate intake of vitamins and minerals

• Limited tobacco and excessive alcohol exposure

• Reduced unnecessary environmental exposure

• Adequate sleep

Liposomal Glutathione provides targeted antioxidant and conjugation support within this broader system.

It is not intended to treat poisoning, chemical exposure, liver failure or another medical emergency.

Healthy Lipid Metabolism and Oxidative Status

Lipids are essential components of cellular membranes and energy metabolism. However, lipids may be vulnerable to oxidative damage.

Glutathione-dependent antioxidant activity helps protect cellular lipids and contributes to a healthy oxidative environment.

Liposomal Glutathione supports normal lipid metabolism as part of a complete routine that includes:

• Balanced nutrition

• Healthy body composition

• Regular exercise

• Adequate omega-3 intake

• Normal glucose metabolism

• Appropriate cholesterol and triglyceride monitoring

It should not replace cholesterol medication or professional treatment for abnormal lipid levels.

Mitochondrial and Cellular-Energy Support

Mitochondria convert nutrients into usable cellular energy. This process naturally generates reactive compounds, including hydrogen peroxide.

Glutathione helps protect mitochondrial and cellular structures from excessive oxidative stress generated during energy production.

Liposomal Glutathione can complement a mitochondrial-support routine that includes:

• Ubiquinol-QH

• Magnesium Glycinate

• Creatine

• O.N.E. Multivitamin

• O.N.E. Omega

• Regular physical activity

• Quality sleep

Glutathione does not act as a stimulant and will not create the immediate energy surge associated with caffeine.

Glutathione and Healthy Aging

The ability to maintain antioxidant balance and cellular resilience is an important component of healthy aging.

Glutathione production and status can be affected by age, nutritional intake, oxidative demand and health conditions. Supporting glutathione availability may help maintain the cellular systems involved in long-term physical function.

Liposomal Glutathione supports a healthy-aging routine by promoting:

• Cellular antioxidant protection

• Liver function

• Mitochondrial resilience

• Normal enzyme activity

• Healthy oxidative balance

• Cellular repair and maintenance

• Long-term metabolic wellness

Glutathione does not stop aging or prevent age-related disease. It provides nutritional support for biological systems involved in cellular protection and resilience.

Liposomal Glutathione vs. NAC + Glycine

Both products support glutathione status, but they do so differently.

Liposomal Glutathione

Liposomal Glutathione provides preformed reduced glutathione directly within a phospholipid delivery system.

It may be preferred by adults who want:

• Direct glutathione supplementation

• A convenient softgel

• Liposomal delivery

• No flavored powder

• A shelf-stable formula

NAC + Glycine

NAC + Glycine provides cysteine and glycine, two amino-acid building blocks the body uses to produce its own glutathione.

It may be preferred by adults who want:

• Glutathione-precursor support

• Larger amounts of NAC and glycine

• Additional respiratory support from NAC

• A vegan powder

• A flavored drink format

One option is not automatically superior for every person. The most appropriate choice depends on dietary preferences, digestive tolerance, supplement format and health goals.

Can Liposomal Glutathione and NAC + Glycine Be Combined?

They support glutathione through complementary approaches: one provides preformed glutathione, while the other provides two of its primary precursors.

However, combining both may be unnecessary for many customers. A healthcare professional can help determine whether using both products provides a meaningful benefit based on health history, oxidative demands and current supplementation.

Liposomal Glutathione Capsules vs. Liquid

Pure Encapsulations offers both capsule and liquid liposomal glutathione formulas, but they are separate products with different ingredients and directions.

This capsule formula provides:

• 250 mg of glutathione per softgel

• 125 mg of essential phospholipids

• One softgel one to two times daily

• Convenient use with meals

• Shelf-stable storage

• No measuring or pumping

The capsule format may be preferable for customers who value convenience, portability and precise serving amounts.

Shelf-Stable Softgel Formula

Unlike some probiotic and liquid products, Liposomal Glutathione softgels do not require refrigeration.

Store the bottle in a cool, dry place and protect it from excessive heat, moisture and direct sunlight.

The softgel format contains gelatin, glycerin, water, calcium carbonate, extra-virgin olive oil and beeswax.

Because it contains gelatin and beeswax, this product is not suitable for vegan or vegetarian diets.

Product Highlights

• 250 mg of Setria® reduced glutathione per softgel

• 125 mg of essential phospholipids per softgel

• 375 mg BioGlute™ liposomal complex

• Supports cellular antioxidant defenses

• Supports liver health

• Supports natural detoxification pathways

• Supports healthy oxidative status

• Supports normal lipid metabolism

• Helps protect cellular structures from free radicals

• Liposomal delivery protects glutathione during digestion

• Shelf-stable

• Convenient once- or twice-daily softgel

• Available in 30- and 60-softgel bottles

• Glutathione produced through corn-glucose fermentation

• Non-GMO

• Free from artificial colors and sweeteners

• Free from unnecessary fillers and preservatives

• Contains soy

• Contains gelatin and beeswax

• Not vegan or vegetarian

Supplement Facts

Each softgel provides:

BioGlute™ proprietary blend of glutathione and essential phospholipids — 375 mg

Providing:

• Setria® reduced glutathione — 250 mg

• Phospholipid complex — 125 mg

Other ingredients include gelatin capsule, glycerin, water, calcium carbonate, extra-virgin olive oil and beeswax.

Contains soy.

Suggested Use

Take one softgel one to two times daily with meals, or as directed by a qualified healthcare professional.

When using two softgels daily, the servings may be divided between two meals.

Do not exceed the suggested use unless professionally directed.

Frequently Asked Questions

What is Pure Encapsulations Liposomal Glutathione?

Pure Encapsulations Liposomal Glutathione is an antioxidant and liver-support supplement that provides reduced glutathione within a protective phospholipid complex.

Each softgel supplies 250 mg of Setria® glutathione and 125 mg of essential phospholipids.

How much glutathione is in each softgel?

Each softgel provides 250 mg of Setria® reduced glutathione.

It also contains 125 mg of essential phospholipids, for a total BioGlute™ liposomal complex of 375 mg.

What is Setria® glutathione?

Setria® is a branded form of reduced glutathione produced through fermentation.

Reduced glutathione is the antioxidant form used by the body to support cellular protection and glutathione-dependent enzyme activity.

What is BioGlute™?

BioGlute™ is the proprietary liposomal complex used in this formula.

It combines Setria® glutathione with essential phospholipids to protect glutathione during digestion and support absorption across intestinal membranes.

What does “liposomal” mean?

A liposome is a small spherical structure formed from phospholipids.

The phospholipids surround the active ingredient and help protect it from digestive degradation while supporting movement across biological membranes.

Is liposomal glutathione better absorbed than regular glutathione?

The liposomal system is designed to improve stability and absorption.

Laboratory testing using an intestinal-cell model showed greater permeability for this formula than for a matching non-liposomal glutathione powder. This does not guarantee the same response in every person.

What does glutathione do?

Glutathione supports:

• Antioxidant defenses

• Neutralization of free radicals

• Normal enzyme activity

• Cellular protection

• Liver function

• Detoxification pathways

• Mitochondrial resilience

• Healthy oxidative balance

Is glutathione the body’s “master antioxidant”?

Glutathione is sometimes described this way because it is widely distributed and participates in numerous antioxidant and detoxification processes.

However, the body uses an interconnected network of antioxidants rather than relying on one compound alone.

Does Liposomal Glutathione support liver health?

Yes. Glutathione is found in high concentrations in liver tissue and supports antioxidant protection and normal Phase II conjugation.

It is not a treatment for fatty liver disease, hepatitis, cirrhosis or another liver condition.

Does glutathione detox the body?

Glutathione supports the body’s normal detoxification pathways, particularly certain Phase II conjugation reactions in the liver.

It does not act as a cleanse or instantly remove accumulated toxins.

What is Phase II detoxification?

Phase II detoxification includes enzymatic reactions that attach molecules such as glutathione to certain compounds.

This process can make the compounds less reactive and support their normal processing and elimination.

Does Liposomal Glutathione support antioxidant defenses?

Yes. Reduced glutathione can donate electrons to reactive compounds and supports glutathione-dependent antioxidant enzymes.

Does glutathione support mitochondrial health?

Yes. Glutathione helps protect mitochondria and other cellular structures from excessive oxidative stress generated during normal energy production.

Does Liposomal Glutathione support healthy aging?

It supports antioxidant defenses, liver function, mitochondrial protection and cellular resilience, all of which are relevant to healthy aging.

It should not be represented as preventing aging or extending lifespan.

Does glutathione support immunity?

Glutathione is involved in normal cellular and immune function, but this specific formula is primarily positioned for antioxidant, cellular and liver support.

It is not intended to prevent or treat infections.

Can glutathione improve skin tone or lighten skin?

Glutathione is sometimes promoted online for skin-lightening purposes, but results are inconsistent and this product is not formulated or marketed as a skin-bleaching treatment.

Changes in pigmentation should be discussed with a qualified dermatologist.

Is Liposomal Glutathione good for gut health?

Its primary benefits relate to antioxidant protection, cellular health and liver detoxification.

It may complement a broader gut and digestive-health routine because liver, bile and intestinal function are interconnected, but it is not a probiotic, digestive enzyme or fiber supplement.

How many softgels should I take?

Take one softgel one to two times daily with meals.

Should Liposomal Glutathione be taken with food?

Yes. The suggested use is with meals.

The phospholipid and oil-based softgel is designed to be taken alongside food.

What is the best time to take Liposomal Glutathione?

Take it with breakfast, lunch or another meal.

When using two softgels daily, divide them between two meals unless a healthcare professional recommends another schedule.

Can I take both softgels together?

The label allows one softgel one to two times daily.

Dividing the servings across two meals may provide a more consistent routine, although individualized professional guidance may differ.

Can I take Liposomal Glutathione every day?

Yes. It is formulated for daily use by adults when appropriate for their health status.

Long-term supplementation should be reviewed with a healthcare professional when medications or medical conditions are involved.

How long does Liposomal Glutathione take to work?

Glutathione is nutritional support rather than a stimulant or fast-acting medication.

The response depends on baseline glutathione status, oxidative demands, diet, consistency and the outcome being evaluated.

Will I feel an immediate effect?

Many people do not feel an immediate sensation from antioxidant supplementation.

Lack of an immediate feeling does not necessarily indicate that the product is not being absorbed or used.

Does Liposomal Glutathione provide energy?

It supports cellular and mitochondrial protection but does not contain caffeine or stimulants.

It should not be expected to produce an immediate energy boost.

Does Liposomal Glutathione contain caffeine?

No caffeine is listed in the formula.

Is Liposomal Glutathione the same as NAC?

No.

Liposomal Glutathione provides preformed glutathione. NAC provides cysteine, an amino-acid precursor the body can use to produce glutathione.

Is Liposomal Glutathione the same as NAC + Glycine?

No.

NAC + Glycine supplies two amino-acid precursors used in internal glutathione synthesis. Liposomal Glutathione provides reduced glutathione directly.

Which is better: Liposomal Glutathione or NAC + Glycine?

Neither option is universally better.

Liposomal Glutathione may be preferred for direct supplementation and softgel convenience. NAC + Glycine may be preferred for precursor support, a vegan formula and the additional nutritional roles of NAC and glycine.

Can I take Liposomal Glutathione with NAC + Glycine?

They may be combined under professional guidance, but using both may be unnecessary for many customers.

Review the complete antioxidant routine before stacking multiple glutathione-focused supplements.

Can I take Liposomal Glutathione with Nrf2 Detox?

Nrf2 Detox supports the body’s endogenous antioxidant-response pathways, while Liposomal Glutathione supplies glutathione directly.

The products may complement one another, but the combination creates a more intensive antioxidant and detoxification-focused routine. Professional guidance is appropriate for regular combined use.

Can I take it with O.N.E. Multivitamin?

Yes. O.N.E. Multivitamin provides foundational vitamins, minerals and antioxidants, while Liposomal Glutathione supplies targeted glutathione support.

Can I take it with O.N.E. Omega?

Yes. Omega-3 fatty acids and glutathione support different aspects of cellular, cardiovascular and healthy-aging wellness.

Can I take it with Ubiquinol-QH?

Yes. Ubiquinol supports mitochondrial energy and antioxidant activity, while glutathione supports broader cellular antioxidant and detoxification systems.

Can I take Liposomal Glutathione with magnesium?

Yes. Magnesium and glutathione serve different nutritional functions and can generally be used within the same routine.

Can I take it with creatine?

Yes. Creatine supports cellular energy, muscle strength and exercise performance, while glutathione supports antioxidant defenses and cellular protection.

Can I take it with Probiotic-5?

Yes. Probiotic-5 supports intestinal microflora, while Liposomal Glutathione supports antioxidant and liver function.

Can I take it with Berberine UltraSorb?

They may be included within the same healthy-aging or metabolic routine.

Customers taking medications or managing glucose, liver or cardiovascular conditions should have the full combination reviewed professionally.

Is Liposomal Glutathione vegan?

No. The softgel contains gelatin and beeswax.

Is Liposomal Glutathione vegetarian?

No. The gelatin softgel makes it unsuitable for vegetarian diets.

Does Liposomal Glutathione contain soy?

Yes. The phospholipid complex is derived from soy, and the label states that the product contains soy.

People with a soy allergy should not assume this product is appropriate.

Does it contain dairy?

Dairy is not listed as an ingredient.

Customers with severe allergies should inspect the current physical label before use.

Is it gluten-free?

Gluten is not listed as an ingredient, and Pure Encapsulations identifies gluten among the unnecessary additives and common allergens excluded from its general formulations.

Customers with severe sensitivities should always confirm the current packaging.

Is Liposomal Glutathione non-GMO?

Yes. It is identified as GMO-free.

Where does the glutathione come from?

The glutathione is produced through corn-glucose fermentation.

Does it contain corn?

The glutathione is sourced through corn-glucose fermentation.

Customers with a severe corn allergy should consult the manufacturer or a healthcare professional regarding suitability.

Does Liposomal Glutathione require refrigeration?

No. The softgel formula is shelf-stable.

Store it in a cool, dry place away from excessive heat and moisture.

Can I travel with it?

Yes. The shelf-stable softgels are convenient for travel.

Avoid leaving the bottle in a hot vehicle, direct sunlight or another location exposed to excessive heat.

Is this the same as Pure Encapsulations Liposomal Glutathione liquid?

No. The liquid and softgel products are separate formulas with different ingredients and directions.

This listing is for the Liposomal Glutathione softgels containing 250 mg of glutathione per capsule.

Can glutathione cause side effects?

Glutathione is generally well tolerated, but possible effects may include:

• Digestive discomfort

• Nausea

• Bloating

• Loose stools

• Headache

• Sensitivity to an ingredient in the softgel

Discontinue use and seek professional guidance if significant or persistent symptoms develop.

Can people with asthma take glutathione?

People with asthma or another chronic respiratory condition should consult a healthcare professional before beginning a concentrated glutathione supplement.

Can people with liver disease use Liposomal Glutathione?

Customers with liver disease, abnormal liver tests or a history of significant alcohol use should consult the healthcare professional managing their condition.

A liver-support supplement should not replace appropriate testing or treatment.

Can people with kidney disease take it?

Customers with kidney disease or reduced kidney function should consult their healthcare professional before adding concentrated antioxidant supplements.

Can Liposomal Glutathione be taken during cancer treatment?

Antioxidant supplements may not be appropriate with every chemotherapy, radiation or immunotherapy treatment.

Customers undergoing cancer treatment should obtain approval from their oncology team before use.

Does glutathione interact with medications?

Glutathione does not have the same extensive interaction profile as many herbs, but individual medications and medical conditions vary.

Customers taking prescription medication should have the product reviewed by a pharmacist or healthcare professional.

Can pregnant customers take Liposomal Glutathione?

Pregnant customers should consult their healthcare professional before use.

Can nursing customers take Liposomal Glutathione?

Breastfeeding customers should obtain professional guidance before using a concentrated glutathione supplement.

Can children take Pure Encapsulations Liposomal Glutathione?

The product is intended for adults ages 18 and older.

A pediatrician should determine whether glutathione supplementation is appropriate for a child or teenager.

Who should consult a healthcare professional before use?

Professional guidance is especially important for customers who:

• Are pregnant or nursing

• Have a soy allergy

• Take prescription medication

• Have liver or kidney disease

• Have asthma or another respiratory condition

• Are receiving chemotherapy, radiation or immunotherapy

• Have an upcoming surgical procedure

• Have a diagnosed medical condition

• Are under 18 years old

How should Liposomal Glutathione be stored?

Store the bottle tightly closed in a cool, dry place away from direct sunlight, excessive heat and moisture.

Refrigeration is not required.

Keep out of reach of children.